Principles of genetic predisposition to malignancies
نویسندگان
چکیده
It is estimated that around 30% of all malignancies are caused by a “high-risk” genetic predisposition [1]. This estimation is based on an evaluation of occurrence of disease among monozygotic twins. If one of them is affected with prostate (PC) or breast cancer (BC), then the probability of occurrence of this disease in the second sibling is 40% for PC and 30% for BC [2]. The concordance among monozygotic twins is even higher when occurrence of malignancies regardless of the site of origin is taken into consideration (e.g. breast cancer in one individual, stomach cancer in the sibling). Genetic susceptibility to cancer can be divided into monogenic and polygenic predisposition.
منابع مشابه
Multiple unrelated malignancies following renal transplantation: an evaluation of four cases.
The risk of de novo malignancy is significantly higher in patients who have undergone organ transplantation than in the general population. Long-term immunosuppressive treatment, in addition to age, genetic predisposition and infectious agents, plays a major role in the development of malignancy. Although skin and hemopoietic system cancers are common, atypical presentations of malignancies may...
متن کاملClinical Assessment and Diagnosis of Germline Predisposition to Hematopoietic Malignancies: The University of Chicago Experience
With the increasing use of clinical genomics to guide cancer treatment and management, there is a rise in the identification of germline cancer predisposition syndromes and a critical need for patients with germline findings to be referred for surveillance and care. The University of Chicago Hematopoietic Malignancies Cancer Risk Team has established a unique approach to patient care for indivi...
متن کاملSarcomas Associated With Genetic Cancer Predisposition Syndromes: A Review.
UNLABELLED : Sarcomas are rare mesenchymal malignancies that demonstrate great clinical and biological heterogeneity. A variety of sarcomas develop in the context of well-defined heritable cancer predisposition syndromes, associations that are often overlooked, given the rarity and diversity of sarcomas and the equivalent relative infrequency of cancer genetic syndromes. This review describes i...
متن کاملChronic lymphocytic leukaemia: clinical-aetiological findings in 66 patients and their families
BACKGROUND Little is known about the aetiology of chronic lymphocytic leukaemia (CLL). The family medical history is a "genomic tool" capturing interactions of genetic susceptibility, shared environment and common behaviours. METHODS A cohort of 66 consecutives patients with CLL (probands) was studied in a medical oncology practice (W.W.) from 1981 until 2005. A German version of the NCI medi...
متن کاملInherited predisposition to myeloid neoplasms
Myeloid neoplasms include myelodysplastic/ myeloproliferative neoplasms (MDS/MPN) and acute myeloid leukemia (AML). While majority of these disorders are still sporadic, it is becoming clear that a subset of them have a germline predisposition and is familial in nature. With the advancement and integration of molecular studies, it has been recognized that approximately 5-10% of hematological ma...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Hereditary Cancer in Clinical Practice
دوره 6 شماره
صفحات -
تاریخ انتشار 2008